Comments on: How to read a genome-wide association study http://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php public personal genomics Sat, 04 Feb 2012 19:33:51 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: Lane Rasberryhttp://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php#comment-165267 Lane Rasberry Sun, 11 Dec 2011 23:56:11 +0000 http://www.genomesunzipped.org/?p=191#comment-165267 Thank you for talking in terms which a layperson can understand. It really is difficult to get non-technical information about GWA studies which non-scientists can understand, and yet since this field has such a broad impact, I think it is important to have educational materials for everyone who wants to learn. Thank you for talking in terms which a layperson can understand. It really is difficult to get non-technical information about GWA studies which non-scientists can understand, and yet since this field has such a broad impact, I think it is important to have educational materials for everyone who wants to learn.

]]> By: Nature + Nurturehttp://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php#comment-106359 Nature + Nurture Tue, 09 Aug 2011 19:33:50 +0000 http://www.genomesunzipped.org/?p=191#comment-106359 [...] a liberating revelation, and I was delighted to encounter it and a few other useful insights on the genomes unzipped blog (also recommended by Dr. Tiwari). The author of the post lists five criteria for evaluating [...] [...] a liberating revelation, and I was delighted to encounter it and a few other useful insights on the genomes unzipped blog (also recommended by Dr. Tiwari). The author of the post lists five criteria for evaluating [...]

]]> By: Your Genome Structure, Not Genetic Mutations, Makes You Differenthttp://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php#comment-101796 Your Genome Structure, Not Genetic Mutations, Makes You Different Fri, 29 Jul 2011 22:17:29 +0000 http://www.genomesunzipped.org/?p=191#comment-101796 [...] a result, most genomic studies, including gold-standard genome-wide association surveys, involve sequences reassembled from small pieces. As with a jigsaw puzzle or a book, however, [...] [...] a result, most genomic studies, including gold-standard genome-wide association surveys, involve sequences reassembled from small pieces. As with a jigsaw puzzle or a book, however, [...]

]]> By: Your Genome Structure, Not Genetic Mutations, Makes You Different | t3knoDorKshttp://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php#comment-101723 Your Genome Structure, Not Genetic Mutations, Makes You Different | t3knoDorKs Fri, 29 Jul 2011 19:15:25 +0000 http://www.genomesunzipped.org/?p=191#comment-101723 [...] a result, many genomic studies, including gold-standard genome-wide organisation surveys, engage sequences reassembled from tiny pieces. As with a jigsaw nonplus or a book, however, [...] [...] a result, many genomic studies, including gold-standard genome-wide organisation surveys, engage sequences reassembled from tiny pieces. As with a jigsaw nonplus or a book, however, [...]

]]> By: Godfreyhttp://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php#comment-31364 Godfrey Wed, 19 Jan 2011 10:04:30 +0000 http://www.genomesunzipped.org/?p=191#comment-31364 Thanks Jeff for the informative article posted, it serves as a good introduction to new entrants into this field. I hope more discussions and elaborations on this subject can come through. Keep up the good job! Thanks Jeff for the informative article posted, it serves as a good introduction to new entrants into this field. I hope more discussions and elaborations on this subject can come through.

Keep up the good job!

]]> By: Friday SNPpets | The OpenHelix Bloghttp://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php#comment-302 Friday SNPpets | The OpenHelix Blog Fri, 23 Jul 2010 12:46:33 +0000 http://www.genomesunzipped.org/?p=191#comment-302 [...] buzz this week on the great newbie guide to GWAS interpretation at Genome Unzipped. [...] [...] buzz this week on the great newbie guide to GWAS interpretation at Genome Unzipped. [...]

]]> By: Vijai Josephhttp://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php#comment-256 Vijai Joseph Thu, 22 Jul 2010 16:50:21 +0000 http://www.genomesunzipped.org/?p=191#comment-256 I apologize for jumping the gun here. I realize that a new article on interpretation of results is a better way to approach them in detail. Thanks Jeff for the wonderful little piece on GWAS. Hope to see many more interesting articles. Thanks Luke JVJ I apologize for jumping the gun here.
I realize that a new article on interpretation of results is a better way to approach them in detail.
Thanks Jeff for the wonderful little piece on GWAS. Hope to see many more interesting articles. Thanks Luke
JVJ

]]> By: Lukehttp://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php#comment-247 Luke Thu, 22 Jul 2010 10:49:49 +0000 http://www.genomesunzipped.org/?p=191#comment-247 @JVJ We have some posts planned discussing genetic epidemiological shizzle in the near future, stay tuned! For the unitiated, the acronyms JVJ are using refer (I think) to: <a href="http://en.wikipedia.org/wiki/Odds_ratio" rel="nofollow">Odds Ratio</a> <a href="http://en.wikipedia.org/wiki/Hazard_ratio" rel="nofollow">Hazard Ratio</a> Genotype <a href="http://en.wikipedia.org/wiki/Relative_risk" rel="nofollow">Relative Risk</a> <a href="http://en.wikipedia.org/wiki/Attributable_risk" rel="nofollow">Population Attributable Fraction</a> @JVJ

We have some posts planned discussing genetic epidemiological shizzle in the near future, stay tuned!

For the unitiated, the acronyms JVJ are using refer (I think) to:

Odds Ratio
Hazard Ratio
Genotype Relative Risk
Population Attributable Fraction

]]> By: Disease as a byproduct of adaptation | Gene Expression | Discover Magazinehttp://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php#comment-235 Disease as a byproduct of adaptation | Gene Expression | Discover Magazine Thu, 22 Jul 2010 07:34:35 +0000 http://www.genomesunzipped.org/?p=191#comment-235 [...] has a lot of moving parts, but the outcome is straightforward. If you haven’t, you might read Genomes Unzipped and its post How to read a genome-wide association study. This is a case where the original [...] [...] has a lot of moving parts, but the outcome is straightforward. If you haven’t, you might read Genomes Unzipped and its post How to read a genome-wide association study. This is a case where the original [...]

]]> By: Vijai Josephhttp://www.genomesunzipped.org/2010/07/how-to-read-a-genome-wide-association-study.php#comment-222 Vijai Joseph Wed, 21 Jul 2010 17:57:54 +0000 http://www.genomesunzipped.org/?p=191#comment-222 Nice intro to GWAS. I think a little more elaboration on the population stratification issues, use of PCA to correct for correlated SNPs, time to event analysis, issues of age matching in some instances can be added. However, the most important lacunae I see is the interpretation of results. A concise summary of OR, HR, GRR and PAF may be useful. Considering the title of the article, I believe that is a required ingredient. Cheers JVJ Nice intro to GWAS. I think a little more elaboration on the population stratification issues, use of PCA to correct for correlated SNPs, time to event analysis, issues of age matching in some instances can be added.

However, the most important lacunae I see is the interpretation of results. A concise summary of OR, HR, GRR and PAF may be useful. Considering the title of the article, I believe that is a required ingredient.
Cheers
JVJ

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